Pox Americana: The Great Smallpox Epidemic of 1775-1782 http://pox.ehistory.org/. Click "Show Time Slider" on the right and manipulate the map to see how small pox epidemics began and spread, and think about where they were concentrated.
Increasing Urbanization 1790-1890 https://www.census.gov/dataviz/visualizations/005/ Hit play at the bottom of the image to see how cities grew in the early United States.
- Surviving History: The Fever by Rachel N. Ponce. http://theappendix.net/special/the-fever This is interactive fiction based on early American Yellow Fever epidemics, so your choices at the end of each section lead you to a different ending. Play through to at least two different endings.